The efficacy of acarbose combined with metformin in treatment of type 2 diabetes

Objective To investigate efficacy of acarbose and metformin in treatment of type 2 diabetes.Methods From January 2010 to January 2013 in our hospital,80 patients with type 2 diabetes were divided into observation group and control group,40 cases in each group,the patients were strictly controlled diet,exercise,on this basis,each0.5 metformin group g,orally,3 times a day in the observation group chew swallow Acarbose 50 mg,3 times a day for12 weeks.Results The two groups of patients before treatment FPG,2hPG,HbA1c were compared between the two groups,the difference was not significant(P 0.05).After 12 weeks of treatment,both groups of patients with FPG,2hPG,HbA1c were significantly lower than before treatment,respectively,and the difference was significant(P 0.05).Observation group after 12 weeks of treatment which FPG,2hPG,HbA1c were reduced more significantly than the control group between the two groups,the difference was significant(P 0.05).The patients were cured 17 cases,effective in 20 cases,3 patients in the control group,15 cases markedly effective in 15 cases,10 cases were observed in patients after treatment,the total effective rate was 92.5% in the control group after treatment,the total effective75.0%,compared the efficacy of two groups after treatment between the two groups,the difference was significant(P 0.05),observed in patients after 12 weeks of treatment efficacy of glycemic control was significantly better than the control group.During 12 weeks of treatment,the observation group 2 cases of hypoglycemia,hypoglycemia rate of 5%in the control group during the treatment of hypoglycemia in 8 cases,hypoglycemia rate of 20.0% in the observation group,the incidence of hypoglycemia was significantly lower than the control groups,between groups,the difference was significant χ2= 4.873,P 0.05).Conclusion In a strict diet,exercise,based on application of acarbose curative treatment of type 2 diabetes,can significantly improve the patient's blood sugar levels and reduce the incidence of hypoglycemia,should be popularized and applied.