Expression of Survivin in Colorectal Carcinoma and its Clinical Significance

Objective To determine the expression of Survivin in the onset and metastasis of colorectal adenocarcinoma,and its clinical significance.Methods From January 2003 to December 2004,immunohistochemical staining,streptavidin-perosidase method,was used to detect the Survivin expression in 58 cases of colorectal carcinoma,12 cases of colorectal adenoma,and 9 cases of normal tissues.Correlation between the expression of Survivin and clinicopathological factors in colorectal cancer was analyzed.Results Survivin was not expressed in normal colorectal tissues.The expression of Survivin in colorectal carcinoma and adenoma was significantly higher than that in norma1 colorectal tissues(P0.05).There was no correlation of Survivin expression with such clinicopathologic factors as age,gender,serosa infiltration,lymph node metastasis,distal metastasis,differentiation level and Dukes stage(P0.05).The Kaplan-Meier survival analysis demonstrated that patients with Survivin-positive tumors had significantly poorer survival rate(51.2%) than those with Survivin-negative tumors(90.9%)(P0.05).Conclusion Abnormal expression of Survivin plays an important role in carcinogenesis and progress of colorectal carcinoma and can be regarded as a good index for the choice of surgery,and assessment of clinical outcomes and prognosis for colorectal cancer patients.