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Expression of nm23-H_(1) in acute leukemia patients and its correlation with multidrug resistance

Shao-Ling Wu, Dianhong Zhang, Xiu-Zhen Jia, Xindong Zhao, Zhao Honguo

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Abstract

Objective To determine the expression of nm23-H_1 gene in acute leukemia patients and to evaluate the relationship between nm23-H_1 expression and multi-drug resistance. Methods Expressions of nm23-H_1 mRNA, MDR1 and MRP were determined in bone marrow cells from 46 acute leukemia patients and 15 normal subjects by semi-quantitative reverse transcription polymerase chain reaction(RT-PCR). Results nm23-H_1 was negative in 15 normal subjects, while it was positively expressed in 43 of 46 acute leukemia patients. The level of nm23-H_1 expression had no significant correlation with that of MDR1 or MRP( r=0.39,0.21,P 0.05). Conclusion The high nm23-H_1 gene expression is related to the occurrence of acute leukemia, but has no correlation with MDR1 or MRP.

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What this paper is about

Objective To determine the expression of nm23-H_1 gene in acute leukemia patients and to evaluate the relationship between nm23-H_1 expression and multi-drug resistance. Methods Expressions of nm23-H_1 mRNA, MDR1 and MRP were determined in bone marrow cells from 46 acute leukemia patients and 15 normal subjects by semi-quantitative reverse transcription polymerase chain reaction(RT-PCR). Results nm23-H_1 was negative in 15 normal subjects, while it was positively expressed in 43 of 46 acute leukemia patients. The level of nm23-H_1 expression had no significant correlation with that of MDR1 or MRP( r=0.39,0.21,P 0.05). Conclusion The high nm23-H_1 gene expression is related to the occurrence of acute leukemia, but has no correlation with MDR1 or MRP.

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Available abstract

Objective To determine the expression of nm23-H_1 gene in acute leukemia patients and to evaluate the relationship between nm23-H_1 expression and multi-drug resistance. Methods Expressions of nm23-H_1 mRNA, MDR1 and MRP were determined in bone marrow cells from 46 acute leukemia patients and 15 normal subjects by semi-quantitative reverse transcription polymerase chain reaction(RT-PCR). Results nm23-H_1 was negative in 15 normal subjects, while it was positively expressed in 43 of 46 acute leukemia patients. The level of nm23-H_1 expression had no significant correlation with that of MDR1 or MRP( r=0.39,0.21,P 0.05). Conclusion The high nm23-H_1 gene expression is related to the occurrence of acute leukemia, but has no correlation with MDR1 or MRP.

Key concepts: Medicine, Leukemia, Acute leukemia, Reverse transcription polymerase chain reaction, Drug resistance, Multiple drug resistance, Polymerase chain reaction, Reverse transcriptase

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Expression of nm23-H_(1) in acute leukemia patients and its correlation with multidrug resistance — Research Paper | ScholarLens