ScholarLens Back to search
2000•Unpublished venueRequires access

EXPRESSION AND CLINICAL IMPLICATION OF MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN IN ACUTE LEUKE-MIA

Yan Qu

Open publisher page 0 citations

Abstract

Objective To study the expression and clinical implication of multidrug resistance associated protein (MRP) in acute Methods Using semi quantitative reverse transcription polymerase chain reaction(RT PCR), the MRP gene expression level was detected in 77 AL patients and 10 cases of a control Results The MRP mean expression level in 77 AL patients was not significantly different compared with that of the control group. MRP mean expression level in patients at relapse was greater than that of untreated patients ( t=5.32, P 0.01). Conclusion The relapse of acute leukemia is correlated to the expression of MRP gene. The overexpression of MRP gene may be as an important prognostic predictor for acute leukemia. [

About this research paper

What this paper is about

Objective To study the expression and clinical implication of multidrug resistance associated protein (MRP) in acute Methods Using semi quantitative reverse transcription polymerase chain reaction(RT PCR), the MRP gene expression level was detected in 77 AL patients and 10 cases of a control Results The MRP mean expression level in 77 AL patients was not significantly different compared with that of the control group. MRP mean expression level in patients at relapse was greater than that of untreated patients ( t=5.32, P 0.01). Conclusion The relapse of acute leukemia is correlated to the expression of MRP gene. The overexpression of MRP gene may be as an important prognostic predictor for acute leukemia. [

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the expression and clinical implication of multidrug resistance associated protein (MRP) in acute Methods Using semi quantitative reverse transcription polymerase chain reaction(RT PCR), the MRP gene expression level was detected in 77 AL patients and 10 cases of a control Results The MRP mean expression level in 77 AL patients was not significantly different compared with that of the control group. MRP mean expression level in patients at relapse was greater than that of untreated patients ( t=5.32, P 0.01). Conclusion The relapse of acute leukemia is correlated to the expression of MRP gene. The overexpression of MRP gene may be as an important prognostic predictor for acute leukemia. [

Key concepts: Multiple drug resistance, Acute leukemia, Gene expression, Reverse transcription polymerase chain reaction, Polymerase chain reaction, Gene, Medicine, Reverse transcriptase

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
EXPRESSION AND CLINICAL IMPLICATION OF MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN IN ACUTE LEUKE-MIA — Research Paper | ScholarLens