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THE SIGNIFICANCE OF MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN(MRP) GENE EXPRESSION IN ACUTE LEUKEMIA

Yuhua Song

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Abstract

Objective To investigate the significance of multidrug resistance associated protein(MRP) gene expression in acute leukemia. Methods A semi quantitative reverse transcription polymerase chain reaction was used to investigate the expression level of MRP for peripheral mononuclear cells of 10 healthy persons and bone marrow mononuclear cells of 48 patients with acute leukemia at presentation and relapse . Results Low level expression of MRP mRNA was found in all normal blood cells. The patients at the time of relapse contained approximately twofold higher levels of MRP mRNA than that of the initially treated patients( t=8.894,P 0.01). Conclusion Increased MRP expression might contribute to leukemia relapse. Obtaining sequential specimens from patients may reveal the significance of MRP overexpression in leukemia relapse. [

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What this paper is about

Objective To investigate the significance of multidrug resistance associated protein(MRP) gene expression in acute leukemia. Methods A semi quantitative reverse transcription polymerase chain reaction was used to investigate the expression level of MRP for peripheral mononuclear cells of 10 healthy persons and bone marrow mononuclear cells of 48 patients with acute leukemia at presentation and relapse . Results Low level expression of MRP mRNA was found in all normal blood cells. The patients at the time of relapse contained approximately twofold higher levels of MRP mRNA than that of the initially treated patients( t=8.894,P 0.01). Conclusion Increased MRP expression might contribute to leukemia relapse. Obtaining sequential specimens from patients may reveal the significance of MRP overexpression in leukemia relapse. [

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Available abstract

Objective To investigate the significance of multidrug resistance associated protein(MRP) gene expression in acute leukemia. Methods A semi quantitative reverse transcription polymerase chain reaction was used to investigate the expression level of MRP for peripheral mononuclear cells of 10 healthy persons and bone marrow mononuclear cells of 48 patients with acute leukemia at presentation and relapse . Results Low level expression of MRP mRNA was found in all normal blood cells. The patients at the time of relapse contained approximately twofold higher levels of MRP mRNA than that of the initially treated patients( t=8.894,P 0.01). Conclusion Increased MRP expression might contribute to leukemia relapse. Obtaining sequential specimens from patients may reveal the significance of MRP overexpression in leukemia relapse. [

Key concepts: Peripheral blood mononuclear cell, Leukemia, Gene expression, Reverse transcription polymerase chain reaction, Messenger RNA, Reverse transcriptase, Multiple drug resistance, Polymerase chain reaction

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