Investigation of clinical value of hemoglobin electrophoresis in the screening of thalassemia

Objective To investigate the clinical value of hemoglobin electrophoresis in the screening of α-thalassemia and β-thalassemia in order to provide information for genetic diagnosis of thalassemia and prevent birth defects.Methods Hemoglobin electrophoresis was performed.The types and quantities of hemoglobin were then analyzed by computer.Coincidence rate between hemoglobin electrophoresis and genetic diagnosis for α-thalassemia and β-thalassemia patients was investigated.Results Hemoglobin electrophoresis indicated that 126 patients with suspectedα-thalassemia and 103 patients with suspected β-thalassemia.Compared with the results of genetic diagnosis,the coincidence rates of α-thalassemia and β-thalassemia were 73.81% and 80.58% respectively.Conclusion Hemoglobin electrophoresis can quantitatively detect HbA,HbF and HbA2,it plays an important role in the screening of thalassemia.Coincidence rate of hemoglobin electrophoresis and genetic diagnosis is high.