Clinical significance of variations of IL-1β,NSE and ICAM-1in the neweborns with hypoxic-ischemic encephalopathy.

Objective:To explore the changes of levelof serum interleukin-1β(IL-1β)neuron specific enolase(NSE) and intercelluar adhesion molecule-1(ICAM-1) in neweborns with hypoxic-ischemic encephalopathy(HIE).Methods: Sixty neonates with hypoxic ischemic encephalopathy(HIE) and twenty normalnewbornswere selected.The levelo serum IL-1β,NSE and ICAM-1 was determined by ELISA.Results:The levels of IL-8,NSE and ICAM-1 in HIE group were much higher than those in control group in acute stage(P0.01).The levels of IL-8,NSE and ICAM-1 in the severe and moderate HIE groups were obviously higher than that in the slight HIE and control groups.In the recovery stage therewas no obvious difference between slight HIE group and control groups.The levels of IL-8,NSE and ICAM-1 in the severe and moderate groups were also decreased in the recovery stage,but also were higher than control and slight HIE groups(P0.01).Conclusion: IL-8,NSE and ICAM-1 may be involved in the occurrence and develop mentof HIE,The levels of IL-8,NSE and ICAM-1 are closely correlatedwith the severity and gradation of HIE.