Expression of HLA-G in cervical cancer and its clinical significance

Objective To detect expression of human leukocyte antigen protein G(HLA-G)in cervical cancer and explore its significance in the development of cervical cancer.Methods The SP immunohistochemical method was used to detect the expression of HLA-G in 54 cervical cancer tissues and 16 normal cervix tissues and its relationship with clinical pathological characteristics of cervical cancer was analyzed.Results The positive expression rate of HLA-G was 66.7%(36/54) in cervical cancer tissues,while no positive expression(0/16)was found in normal cervix tissues.The positive expression rate of HLA-G was closely related with clinical stage and differentiation degree(P0.05),but was not related with age,histological classification,and lymph node metastasis(P0.05).Conclusion Expression of HLA-G in cervical tumors is significantly higher than that in normal cervix tissues,and HLA-G plays an important role in the development of cervical cancer.