Detection and analysis of antibiotic resistance of ESBLs-producing and AmpC-producing Klebsiella pneumoniae

Objective To explore the antibiotic resistance of ESBLs-producing and AmpC-producing Klebsiella Pneumoniae in Liaocheng area and conduct clinical medication. Methods Aretrospective review was performed to analyze the clinical distribution of 156 isolates of Klebsiella pneumoniae. The strains were identified by using the automatic microorganism analyzer vitek2-compact. Bacteria's drug susceptibility was performed by K-B method. Then ESBLs and AmpC were detected by confirmatory test recommended by CLSI / NCCLS and three-dimensional test,respectively. Results In 156 strains of Klebsiella pneumoniae,54 strains( 34. 6%) isolates produced ESBLs,6 strains( 3. 8%) isolates produced AmpC and 3 strains( 1. 9%) isolates produced both. All isolates of Klebsiella pneumoniae were sensitive to imipenem and piperacillin / tazobactam. Enzyme production strains resistant to antibiotics of the removing rate of imipenem and piperacillin / tazobactam were higher than that of no enzyme producing strain. Conclusion In Liaocheng area ESBLs-producing and AmpC-producing Klebsiella Pneumoniae had emerged. Enzyme producing strains were still highly resistant to many antibiotics,which should be paid attention in clinic.