Relationship between LDL-C/HDL-C and severity of coronary artery disease

Objective To explore the relationship between blood lipids and the severity of coronary artery disease. Methods A total of 4 751patients with chest pain were divided into two groups according to the results of coronary angiography:coronary artery disease group(n=3 402stenosis in one main branch stenosis≥50%)and control group(stenosis50%,n=1 349).According to the number of coronary artery stenosis,the coronary artery disease group was divided into three subgroups(group 1:1branch stenosis;group 2:2branch stenosis;and group 3:3or more than 3branch stenosis).The serum total cholesterol(TC),triglycefides(TG),high density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)were determined and LDL-C/HDL-C was calculated.The relationship between lipids and the severity of coronary artery stenosis was analyzed by Spearman correlation analysis,and the risk factors of coronary artery disease were analyzed by multiple-stepwise logistic regression analysis.Results The levels of TG,TC,LDL-C and the ratio of LDL-C/HDL-C in the coronary artery disease group were significantly lower than those in the control group(P0.01).LDLC/HDL-C ratio increased with the increase of diseased branches in the disease group(P0.001),and the number of diseased branches was positively correlated with the ratio of LDL-C/HDL-C(R=0.25,P0.01).Logistic multiple regression analysis showed that high LDL-C/HDL-C level was an independent risk factor for coronary heart disease.Conclusion LDL-C/HDL-C ratio is an independent risk factor for coronary heart disease and it is positively correlated with the severity of coronary artery lesions.