Elevated blood lipids are associated with the severity of coronary stenosis in patients with coronary heart disease

Objective To evaluate Coronary lesions in patients with coronary heart disease with dislipidemia.Methods 9847 consecutive patients underwent coronary angiography were selected,including 6419(65.2%) with coronary artery disease.CAD severity was assessed by the Gensini score with 50% stenosis in the angiography.Preoperative triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) levels were measured.Comparative analysis of the coronary lesions and the extent of coronary stenosis with lipid levels was made.Results By analysis of 6419 cases of coronary heart disease,patients with lower HDL-C levels and higher TC,LDL-C levels were found to have more severe coronary lesions and the levels of TC and LDL-C were positively related with the severity of coronary artery stenosis and the Gensini score.Multiple liner regression analysis showed that Gensini score was independently negatively correlated with HDL-C(β=-0.075,OR:-5.580,95%CI:-7.541--3.618,P0.001)but independently positively correlated with LDL-C(β=0.067,OR:2.712,95%CI:0.943-4.481,P=0.003).TG(β=0.002,OR:0.067,95%CI:-0.689-0.822,P=0.863) and TC(β=0.034,OR:1.080,95%CI:-0.392-2.553,P=0.150) showed no correlation with Gensini score.Conclusions TG,LDL-C,TC as an independent risk factor for coronary heart disease.Gensini score was independently negatively correlated with HDL-C,but was positively related with LDL-C.TG and TC were not correlated with Gensini score.Control of blood lipids to prevent coronary heart disease showed positive significance.