Clinical Observation of Oxaliplatin(L-OHP)Combined with Leucovorin and 5-fluorouracil for the Treatment of 37 Patients with Advanced Gastric Carcinoma

Objective: To observe the efficacy and toxic reaction of oxaliplatin(L-OHP) combined with leucovorin and 5-fluorouracil in the treatment of 37 patients with advanced gastric carcinoma.Method: All patients were treated with L-OHP(85㎎/㎡,ivgtt,d1)combined with leucovorin(200㎎/㎡,ivgtt,d1 to d2),fluorouracil(400㎎/㎡,iv,followed by 5 Fu 600㎎/㎡ continuous venous infusion 22 hours,d1 to d2),repeated every 14 days,twice for one recycle.The treatment was finished after 2 recycles.Result: Complete response was achieved in 2 cases,partial response in 16 cases ,stable in 13 cases and progression in 6 cases.The overall response rate was 48.65%.The main toxic reactions were myelosupression,nausea,vomiting and neuro-sensory toxicity.Conclusion: Oxaliplatin(L-OHP)combined with leucovorin and 5-fluorouracil is effective in the treatment of advanced gastric carcinoma.Its toxic effect is tolerable.