CHANGES AND CLINICAL SIGNIFICANCE OF INFLAMMATORY FACTORS IN PATIENTS WITH ANGINA PECTORIS

Objective To explore the changes and clinical significance of inflammatory factors in the occurrence and development of angina pectoris. Methods Sixty patients with coronary heart disease(CHD) accompanying angina confirmed by coronary arteriography(CAG),of whom,28 were assigned to stable-angina(SA) group and 32 to unstable angina(UA) group.The serum interleukin(IL)-6,8,tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP) were measuredusing GC-911 γ counter assay and immune scattering ratio turbidimetric technique,and white blood cells(WBC) of peripheral blood were detected as well.Twenty healthy subjects served as controls. Results Compared with the controls,the serum levels of inflammatory cytokines(IL-6,IL-8,TNF-α,hs-CRP) and WBC in patients with angina elevated(t=2.986-6.069;P0.01),and that in patients in UA group were higher than those in SA group(t=2.163-3.255;P0.05,0.01).The hs-CRP and IL-6 as well as WBC in UA group were positively correlated(r=0.376,0.366;P0.05),and the hs-CRP was positively correlated with the WBC in SA group(r=0.515,P0.01). Conclusion Inflammatory response involves in the occurrence and development of angina.A monitoring of the levels of inflammatory indicators is of a certain value of reference for clinical classification and prognostic prediction of this condition.