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Change of serum level of TNF-α and CRP in patients with unstable angina

Hong Yan

Abstract

Objective:To explore the clinical significance of tumor necrosis factor α(TNF-α) and C-reactive protein (CRP) in patients with unstable angina(UAP). Methods:Serum levels of TNF-α and CRP were determined in 38 patients with UA P(UAP group) 、30 patients with stable angina (SAP group) and 30 healthy (health group) by immunoturbidimetry and ELISA. Results: Serum levels of TNF-α and CRP were significantly higher in patients with UAP than those in patients with SAP and healthy(P0.01 all),those of SAP group also more than those of heath group(P0.01);② Regression analysis shows significantly positive correlation between TNF-α and CRP (r=0.62, P0.01).Conclusion:The results demonstrate that there are activation of inflammatory cells and inflammation in patients with UAP, serum levels TNF-α and CRP can be used as marked of unstable coronary artery pathological change.

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Key concepts: Medicine, Unstable angina, Tumor necrosis factor alpha, Internal medicine, C-reactive protein, Pathological, Clinical significance, Inflammation