Study Mycoplasma infection in genitourinary tract and the antimicrobial susceptibility test in vitro

Objective:To evaluate the infection and resistance of ureaplasma urealyticum (Uu) and mycoplasma hominis (Mh), probe into the mechanism of resistance, in order to determine the most suitable treatment.Methods:Mycoplasma in genitourinary tract of 1 612 patients who were suspected non-gonococcal urethritis (NGU) was detected, and proceeded the antimicrobial susceptibility test (AST) in positive samples. Results:In 1 612 tested samples, 1 160 cases were Mycoplasma positive (72%). The infective rates of Uu, Mh, Uu+Mh were 71%, 19.7%, 9.3% respectively. 75.5% in male were Uu infection, but 68% in female. 22.1% in female were Mh infection, but 16.0% in male. The total infective rates in female (59.6%) were higher than in male(40.4%), and the difference is significance (P0.05). Uu and Mh were susceptible to Doxycycline, Josamycin and Pristinamycin, and resistance rates were below 5%. Uu and Mh appeared high resistance rates to fluoroquinolones. Mh had high resistance rates to Erythromycin, Azithromycin and Clarithromycin, but Uu had high susceptible rates to them. Conclusions:Mycoplasma is one of pathogens in NGU. We advise to do AST when test Mycoplasma, and further study the mechanism of resistance. The new generation drugs of Tetracycline are recommended as the first line drugs in treating the infection of Uu and Mh.