Effects of Polyphenol(TP) on Growth Inhibition,Anti-Oxidation and Immune Regulation of Lewis Lung Cancer in Mice

Objective: To investigate the effects of Tea Polyphenol(TP) on inhibition of tumor growth, anti-oxidation and immune regulation in tumor-bearing mice. Methods: TP was administered by gastriclavage to C57BL/6J mice implanted with Lewis lung cancer. Results: Inhibitory rates of TP at doses of 125 mg/kg and 250 mg/kg were 27.2% and 18.8% respectively, with significance over controls at dose of 125 mg/kg( P 0.05). In tumor-bearing mice, weight of thymus and its index were declined and spleen index was increased, while serum MDA levels were increased significantly at the same time, SOD and GSH-Px activities had no change after mice were beard tumor. Serum MDA levels of tumor-bearing mice were decreased significantly and SOD and GSH-Px activities were increased by TP. Thymus index and spleen index were decreased at the same time. Conclusion: TP could inhibit the growth of Lewis lung cancer, the underlying mechanism of which was associated with anti-oxidation.