Distribution and drug resistance of pathogens cultured from blood samples in cancer patient

Objective To understand the antibiotic resistance and distribution of pathogenic bacteria isolated from blood culture in cancer patient and to provide a basis for clinical diagnosis and treatment.Methods All the blood samples were collected from the patients between 2006 and 2009.Pathogenic bacteria were identified and the drug sensitivity test was performed.Results Total 385 pathogenic bacteria were isolated in 4 405 blood samples.The positive rate was 8.7%.Among them,109 strains of Gram negative bacteria were isolated and accounted for 28.3%.Fungi and anaerobe accounted for 12.0% and 5.7% respectively.The antibiotic resistance rate of Gram negative bacteria against carbapenem was in a higher level.The effect of vancomycin and linezolid to Gram positive bacteria was better.There were no strains resistant to vancomycin,but 5.6% of enterococci was in intermediate.Conclusion The pathogenic bacteria of blood culture in cancer patients spread widely.Escherichia coli and coagulase negative staphylococcus(CNS)are most frequent and the drug resistance is serious.More attention should be paid to monitor the bacterial resistance of frequently used drugs.