The expressions of Bag-1 and HSP70 protein in cervical intraepithelial neoplasia and cervical carcinoma

Objective:To investigate the expression of Bag-1 and HSP70 in cervical intraepithelial neoplasia and invasive cervical carcinoma. Methods:S-P immunohistochemistry was used to detect Bag-1,HSP70 proteins in 36 cases of cervical cancer,64 cases of CIN and 20 cases of normal control. Results:The positive rates of Bag-1 were 15.00%(3/20),48.72% (19/39),80.00% (20/25),83.33% (30/36) in normal control,CINⅠ-Ⅱ,CINⅢ and cervical carcinoma respectively. Compared with each group,expression of Bag-1 was significantly enhanced (P0.05),but the difference of positive frequency of Bag-1 in CINⅢ and cervical carcinoma was not significant (P0.05); The positive rates of HSP70 were 15.00% (3/20),48.72% (19/39),72.00% (18/25),86.11% (31/36) in normal control,CINⅠ-Ⅱ,CINⅢ and in cervical carcinoma respectively. Compared with each group,expression of HSP70 was significantly enhanced (P0.05),but the positive frequency of HSP70 in CINⅢ and cervical carcinoma was not significant (P0.05); There was significant correlation between Bag-1 and HSP70 in cervical carcinoma (r=0.393,P=0.016). Conclusion:Bag-1 and HSP70 overexpression may play an important role in the pathogenesis and development of cervical cancer. Bag-1 and HSP70 protein in the development of cervical carcinoma enhance each other.