The study of treating chronic obstructive pulmonary disease complicated with pulmonary infection using bronchoalveolar lavage combined with invasive mechanical ventilation

Objective:To study effects of invasive mechanical ventilation combined with bronchoalveolar lavage treating patients with chronic obstructive pulmonary disease complicated with pulmonary infection.Methods:58 patients with chronic obstructive pulmonary disease complicated with pulmonary infection were divided into treatment group(30 cases) and control group(28 cases).Control group were given conventional therapy and invasive mechanical ventilation,treatment group were given bronchoalveolar lavage on the basis of invasive mechanical ventilation every one or two days.Arterial blood gas index(pH,PaCO2,PaO2),moist rales,amount of expectoration,WBC,procalcitonin and the time of invasive mechanical ventilation were measured before and after treatment.Results:Arterial blood gas index(pH,PaCO2,PaO2) were significantly improved in both group 4 hours after treatment.But the level of them in treatment group were higher than that in control group.A greater degree of improvement were obtained 48 hours after treatment(P0.05),the level of them in treatment group were higher than that in control group(P0.05).The levels of WBC and procalcitonin of treatment group were significantly lower than that of control group 3 days after treatment(P0.05).The time of invasive mechanical ventilation of treatment group were significantly lower than that of control group(P0.05).Moistrales,amount of expectoration were decreased in both group after treatment,the changes of treatment group is more significant.Conclusion:Bronchoalveolar lavage combined with invasive mechanical ventilation were more effective than invasive mechanical ventilation only in the treatment of patients with chronic obstructive pulmonary disease complicated with pulmonary infection.It can effectively correct respiratory failure,improve the symptoms of patients,control pulmonary infection,shorten the time of mechanical ventilation.