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2000•Journal of Modern RehabilitationRequires access

Experimental study of ICAM-1 expression after focal cerebral ischemia and reperfusion in the rat and the interference effect of methylprednisopone

JU Yiran

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Abstract

Objective:To study the function of ICAM-1 in cerebral ischemiareperfusion injury and the influences by methylprednisolone(MP).Methods:MCA(Middle Cerebral Artery)occlusion was induced by advansing a nylon filament into the internal carotid artery.ICAM-1 expression was detected by immunohistochemical method,and histopathological changes were studied.Results:ICAM-1 expression was clearly identified on microvessels in the ipsilateral hemisphere of the MCAocclusion animals.The numbers of ICAM-1-positive microvessels and infiltrating leukocytes were decreased in MPtreated animals,and tissue injury was relatively reduced. Conclusion :Focal cerebral ischemia reperfusion enhances ICAM-1 expression on brain microvessels.MP reduced ICAM-1 expression and leukocyte infiltration in ischemic tissue.

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Objective:To study the function of ICAM-1 in cerebral ischemiareperfusion injury and the influences by methylprednisolone(MP).Methods:MCA(Middle Cerebral Artery)occlusion was induced by advansing a nylon filament into the internal carotid artery.ICAM-1 expression was detected by immunohistochemical method,and histopathological changes were studied.Results:ICAM-1 expression was clearly identified on microvessels in the ipsilateral hemisphere of the MCAocclusion animals.The numbers of ICAM-1-positive microvessels and infiltrating leukocytes were decreased in MPtreated animals,and tissue injury was relatively reduced. Conclusion :Focal cerebral ischemia reperfusion enhances ICAM-1 expression on brain microvessels.MP reduced ICAM-1 expression and leukocyte infiltration in ischemic tissue.

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Available abstract

Objective:To study the function of ICAM-1 in cerebral ischemiareperfusion injury and the influences by methylprednisolone(MP).Methods:MCA(Middle Cerebral Artery)occlusion was induced by advansing a nylon filament into the internal carotid artery.ICAM-1 expression was detected by immunohistochemical method,and histopathological changes were studied.Results:ICAM-1 expression was clearly identified on microvessels in the ipsilateral hemisphere of the MCAocclusion animals.The numbers of ICAM-1-positive microvessels and infiltrating leukocytes were decreased in MPtreated animals,and tissue injury was relatively reduced. Conclusion :Focal cerebral ischemia reperfusion enhances ICAM-1 expression on brain microvessels.MP reduced ICAM-1 expression and leukocyte infiltration in ischemic tissue.

Key concepts: ICAM-1, Middle cerebral artery, Ischemia, Immunohistochemistry, Pathology, Infiltration (HVAC), Medicine, Reperfusion injury

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Experimental study of ICAM-1 expression after focal cerebral ischemia and reperfusion in the rat and the interference effect of methylprednisopone — Research Paper | ScholarLens