Effects of the recombinant porcine lactoferrin on the interleukin-1 and interleukin-2 in serum of weanling pigs

Two experiments were conducted to evaluate the influence of the recombinant lactofrrin on the interleukin-1 and interleukin-2 in serum of weanling pigs.90 weanling piglets of 28 days of weanling age were blocked by weight and allotted to three dietary treatments and fed for thirty days.The dietary treatments were:A.basal diet,B.basal diet+20 mg/kg flavomycin+110 mg/kg chlortetracycline,C.basal diet+730 mg/kg rPLF.In experiment 1,Duroc×Landrace×Jia piglets were used.In experiment 2,Duroc×Landrace×Yorkshire piglets were used and separated into two stages.The first stage was from 1 to 15 days,the second was from 16 to 30 days after weanling.After feeding trial,three gilts whose weight were close in each treatment were slaughtered.The level of interleukin-1 and interleukin-2 in serum were determined.The results showed that in contrast with control,the level of IL-2 in experiment 1 increased by 46.64% with rPLF (P0.01),and the level of IL-2 in serum in the two stages of experiment 2 increased significantly(P0.05).The level of IL-1 also increased but not significant difference in statistics in the two experiments.The two experiments indicated that diet with rPLF increased the level of IL-2 and IL-1 in serum,and enhanced the immunity of the weanling pigs.