2000•Unpublished venueRequires access
Preparation of 5-fluorouracil-loaded Chitosan Microspheres
Liang Gui
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Abstract
Chitosan microspheres loaded with 5_Fu were prepared with two different methods. Microspheres A were prepared by cross_linking_emulsion method. Microspheres B were prepared by two steps:BSA microspheres were first made and then covered with chitosan. The size of the two kind of microspheres was about 3.5～6.5 μm and 0 6～2.8 μm respectively. The drug loading was about 10.86% and 8.52% respectively. 5_Fu release from microspheres B was sustained in phosphate buffer solution(pH 7 4) and it was ruled by Higuchi equation.