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Genetic polymorphism of CYP2C9 and the risk of lung cancer

Min Bao

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Abstract

Objective To evaluate the relationship between the polymorphism of genes CYP2C9 and the susceptibility to lung cancer. Methods The patients with lung cancer (LC group,n=56) diagnosed clinically or/and cytologically were selected. And the control group(n=42) were also selected from the same areas. The genotype frequencies of AvaⅠ and Nsi Ⅱwere analysed with Polymerase Chain Reaction-Restriction Fragment length Polymorphlism (PCR-RFLP) in the LC group and the control group. Results The mutation genotype of CYP2C9~*3 was found in LC group (8.93%), which was not significantly higher than that in the control group (4.76%), and the OR=1.96(95%CI=0.63-10.33). The mutation genotype of CYP2C9~*2 was not found in both the LC group and the control group. Conclusion There was no association between the mutation genotype of CYP2C9~*3 and the susceptibility of lung cancer in this study.

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What this paper is about

Objective To evaluate the relationship between the polymorphism of genes CYP2C9 and the susceptibility to lung cancer. Methods The patients with lung cancer (LC group,n=56) diagnosed clinically or/and cytologically were selected. And the control group(n=42) were also selected from the same areas. The genotype frequencies of AvaⅠ and Nsi Ⅱwere analysed with Polymerase Chain Reaction-Restriction Fragment length Polymorphlism (PCR-RFLP) in the LC group and the control group. Results The mutation genotype of CYP2C9~*3 was found in LC group (8.93%), which was not significantly higher than that in the control group (4.76%), and the OR=1.96(95%CI=0.63-10.33). The mutation genotype of CYP2C9~*2 was not found in both the LC group and the control group. Conclusion There was no association between the mutation genotype of CYP2C9~*3 and the susceptibility of lung cancer in this study.

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Available abstract

Objective To evaluate the relationship between the polymorphism of genes CYP2C9 and the susceptibility to lung cancer. Methods The patients with lung cancer (LC group,n=56) diagnosed clinically or/and cytologically were selected. And the control group(n=42) were also selected from the same areas. The genotype frequencies of AvaⅠ and Nsi Ⅱwere analysed with Polymerase Chain Reaction-Restriction Fragment length Polymorphlism (PCR-RFLP) in the LC group and the control group. Results The mutation genotype of CYP2C9~*3 was found in LC group (8.93%), which was not significantly higher than that in the control group (4.76%), and the OR=1.96(95%CI=0.63-10.33). The mutation genotype of CYP2C9~*2 was not found in both the LC group and the control group. Conclusion There was no association between the mutation genotype of CYP2C9~*3 and the susceptibility of lung cancer in this study.

Key concepts: Genotype, Lung cancer, Restriction fragment length polymorphism, Internal medicine, Gastroenterology, Polymorphism (computer science), Polymerase chain reaction, Genetics

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