Single Nucleotide Polymorphisms of CYP2D6 C188T and Susceptibility to Lung Cancer

[Objective] To analyze the correlation between the single nucleotide polymorphism of CYP2D6 C188T and the risk of lung cancer, and explore the sensitive genotype of lung neoplasm. [Methods] A case-control study of 118 lung cancer patients and 118 control subjects(matched for sex and age)was carried out to investigate the relationship between C188T and lung cancer taking by PCR-RFLP to identify the genotype frequencies. [Results] The frequency of 188T allele in case and control groups was 53.39% and 61.86% respectively; and that of T188/T genotype was 29.66% and 42.38%. The differences of 188T allele and T188/T genotype distribution were not statistically significant between cases and controls. Non-T188/T genotype (including C188/C and C188/T genotype) was connected with lung cancer moderately and the OR after adjusted by gender, age and smoking was 1.70(95%CI: 1.01-2.92), especially with lung squamous carcinoma the OR was 2.49(95%CI: 1.07-5.79). After stratification analysis according to smoking and adjusted by gender and age it revealed that Non-T188/T genotype was associated with significant increased risk in non-smokers and light-smokers group with OR=2.28(95%CI: 1.08-4.81)and OR=3.64(95%CI: 1.13-11.79)respectively.There was no interaction between non-T188/T genotype and smoking on susceptibility to lung cancer(x2=1.46,P=0.227). [Conclusion] T188/T genotype may act as a protective factor in non-smokers or light-smokers subgroups and in lung squamous carcinoma cases.