Significance of Sentinel Lymph Node Biopsy with Methlene Blue in Breast Cancer

Objective To study the significance of sentinel lymph node biopsy(SLNB) with methylene blue in breast cancer.Methods During the axillary lymph node dissection(ALND) operation,2 ml 1% methylene blue was injected around the lumen.All stained lymph nodes were considered as SLN.All the acquired lymph nodes,including SLN or NSLN,underwent phathological examination.Results SLN were identified in 95 of 108 patients(87.9%).Histologic status of the SLNs accurately predicted axiliary nodes status with an accuracy rate of 95.7%(91/95).The false negative rate is 6.5%.and false positive was 0.4 false negative cases were skip metastasis.The positive and negative metastasis rates were 34.6% and 65.3% for SLN,39.8% and 60.2% for axillary lymph nodes,not showing a significant difference between them(P0.05).Conclusion SLN could accurately predict the axillary node status in patients with breast cancer.