Track in Sentinel Lymph Node of Breast Cancer by Methylene Blue

Objective To probe into the feasibility of sentinel lymph node(SLN) biopsy by injection of blue dye in the treatment of breast cancer and the accuracy in predicting axillary lymph node(ALN) metastasis.Methods We performed sentinel lymph node biopsy(SLNB) in 66 patients with breast cancer of clinical stage 0-Ⅱ.The mapping procedures and SLNB were performed using subareolar injection of Methylene blue dye the site of the primary breast cancer,followed by the axillary lymph node dissection(ALND).All of the SLN and ALN were evaluated pathologically after the operations.Results Among 66 cases,62 were checked out sentinel lymph node and the positive rate was 93.9%(62/66).The axillary status was accurately predicted by SLNs(53/62);Sensitivity in this group was 91.9%(62/66);False negative rate 12.2%(5/41);False positive rate 0(0/41).Conclusion SLN biopsy is technically possible in patients with breast cancer.Most of SLNs can probably reflect the histological characteristics of the axillary lymph nodes.