Application of CT perfusion imaging in hyperacute ischemic cerebrovascular disease

Objective To investigate the application of computed tomography perfusion imaging(CTPI)in hyperacute ischemic cerebrovascular disease. Methods Conventional computed tomography (CT) and CTPI were performed within 6 hours of symptom onset in 46 patients with cerebrovascular disease. Results In 46 cases,5 cases diagnosed as cerebral infarction obtained regular CT positive results.In 41 having regular CT negative results,29 had cerebral infarction,and the other 12 had transient ischemic attack(TIA).In 16 cases with CTPI negtive,12 were diagnosed as having TIA and the others having small infarction volume.30 cases were confirmed by CTPI as having ischemic lesions.In 30 cases,5 had ischemic lesions larger in CTPI than in regular CT and 25 had regular CT negtive results.The regional cerebral blood flow(rCBF),time to peak(TP),mean transit time(MTT)in 30 cases with CTPI positive were found obviously changed.The side of ischemic lesion as compared with the opposite side,and the core of ischemic lesion as compared with peripheral zone were found changed significantly( P 0.05). Conclusions CTPI can be used to diagnose hyperacute cerebral infarction and to distinguish TIA.By analysis on blood perfusion statue,CTPI is possibly used to determine the position,area and the range of the ischemic lesion and penumbra.It should be meaningful for evaluating prognosis and giving treatment to the patients with hyperacute ischemic cerebrovascular disease.