Expression and significance of Survivin,PTEN and mutant type P53 in human brain astrocytoma

Objective To investigate the expressions of apoptosis inhibitor gene-Survivin and tumor suppressor gene-PTEN,mutant type P53 in human brain astrocytoma and the relationship between these genes and the pathological features of astrocytoma.Methods SP immunohistochemical method was used to detect the expression of Survivin,PTEN and mutant type P53 gene in 15 cases of normal brain tissue and 40 cases of cerebral astrocytoma.Results The positive rates of Survivin,PTEN and mutant type P53 in normal brain tissue were 0%,100% and 0% respectively.The positive rates in astrocytoma were 52.5%,60.0% and 45.0% respectively.There was a significant difference in the expressions of Survivin,PTEN and mutant type P53 between normal brain tissue and astrocytoma.The expressions of Survivin,P53 were increased with the increase of tumor's grade,however,the expression of PTEN was decreased.Conclusion Survivin,PTEN and mutant type P53 in the occurrence and development of astrocytoma play an important role and the positive rates of Survivin,PTEN and mutant type P53 in astrocytoma are correlated with astrocytoma's grade.