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2010•Journal of Nongken MedicineRequires access

Expression and significance of PTEN protein in brain astrocytoma

Xiaopeng Yang

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Abstract

Objective:To investigate PTEN protein expression in brain astrocytoma with various grades.Methods:Expression of PTEN protein was studied by immunohistochemical staining in 46 cases of astrocytoma.Results:The positive rate of PTEN protein was 63.4% in astrocytoma;The positive rates decreased with progression of pathological grade(p0.01);The pathological grade was associated with PTEN protein expression in astrocytoma(r=-0.612,p0.01).Conclusion:PTEN gene mutation and deletion play a key role in astrocytoma pathogenesis and progression;PTEN expression is closely correlated to tumor differentiation in astrocytoma.

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Objective:To investigate PTEN protein expression in brain astrocytoma with various grades.Methods:Expression of PTEN protein was studied by immunohistochemical staining in 46 cases of astrocytoma.Results:The positive rate of PTEN protein was 63.4% in astrocytoma;The positive rates decreased with progression of pathological grade(p0.01);The pathological grade was associated with PTEN protein expression in astrocytoma(r=-0.612,p0.01).Conclusion:PTEN gene mutation and deletion play a key role in astrocytoma pathogenesis and progression;PTEN expression is closely correlated to tumor differentiation in astrocytoma.

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Available abstract

Objective:To investigate PTEN protein expression in brain astrocytoma with various grades.Methods:Expression of PTEN protein was studied by immunohistochemical staining in 46 cases of astrocytoma.Results:The positive rate of PTEN protein was 63.4% in astrocytoma;The positive rates decreased with progression of pathological grade(p0.01);The pathological grade was associated with PTEN protein expression in astrocytoma(r=-0.612,p0.01).Conclusion:PTEN gene mutation and deletion play a key role in astrocytoma pathogenesis and progression;PTEN expression is closely correlated to tumor differentiation in astrocytoma.

Key concepts: PTEN, Astrocytoma, Immunohistochemistry, Pathological, Cancer research, Pathogenesis, Pathology, Biology

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