The epidemic characteristics of Bacillary dysentery and drug resistance of Shigella

To investigate the epidemic characteristics and antibiotic resistance of Shigella group causing Bacillary dysentery in patients in recent years for the guidance of clinical treatment and prevention and control of bacillary dysentery.Suspicious strains isolated from Shigella and Salmonella agar culture were identified to the group by VITEK-32 instrument and serum agglutination of bacteria,and K-B method was used to study the antimicrobial resistance.The test of paper confirm was used to studuy the producing extended-spectrum β-lactamases(ESBLs),and three-dimensional test for detection AmpC β lactamases(AmpC enzymes).Among 279 infected patients,the most common groups were Shigella sonnei(201 striains,account for 72.4%) and Shigella flexneri(76 strains,account for 27.2%),and the most infected patients were 0 to 11 year-old(account for 71.3% of the total infection rate,199/279).High incidence from July to November.The results of antibiotic susceptibility test in vitro showed the resistance rates of Shigella flexneri and Shigella sonnei to ampicillin,piperacillin and cotrimoxazole were higher than 60%,and to ciprofloxacin and levofloxacin were low than 40%,In addition,no isolate was resistant to piperacillin/tazobactam and imipenem.151 strains were confirmed to be ESBLs positive(account for 54.1% of the total infection rate,151/279),but not AmpC enzyme.In our hospital,the major patient groups infected by Shigella flexneri and Shigella sonnei were infants and young children,and Shigella sonnei had an increasing tendency.The sensitivity of the two kind of Shigella to some antibiotics varied greatly.Therefore,clinician should selected reasonably antibiotics according to the bacteria identification and drug susceptibility of Shigella.