Influence of rosuvastatin on von wilebrand factor and plasma thrombomodulin( TM) levels of acute cerebral infarction patients

Objective To discuss the effect of rosuvastatin on von wilebrand factor and plasma thrombomodulin( TM) levels of acute cerebral infarction patients. Methods 76 cases of acute cerebral infarction patients from June 2012to May 2013 in our hospital were divided into observation group and control group. The patients of the two groups were given basic treatment like intracranial pressure control,blood pressure and blood sugar maintenance,anti-platelet aggregation,brain cells nutrition etc. The patients of the observation group were given 100 mg rosuvastatin tablets per time,once daily for 2 weeks at the same time. The changes of vWF and TM levels in plasma of patients of the two groups were compared before and after medical treatment,and the curative effect and security were carried on as well. Results After 2weeks' medical treatment,the vWF and TM level of the two groups declined obviously than before treatment( P 0. 05 or P 0. 01),and the declining or rising rate of observation group was much higher than that of control group( P 0. 05).Meanwhile,the total curative efficiency of observation group( 94. 74%) was much higher than that of control group( 78.95%)( χ2= 4. 15,P 0. 05). 3 and 5 cases of untoward effect appeared in control group( 7. 89%) and observation group( 13. 16%) separately during the medical treatment with light symptom but no serious untoward effect. The ADR occurrence rates of the two groups had no significant difference( χ2= 0. 14,P 0. 05). Conclusion Rosuvastatin has reliable curative effect on acute cerebral infarction with high security,whose mechanism of action is to reduce vWF and TM level in plasma,protect and improve the vascular endothelial function.