The Effect of Mosapride Combined with Omeprazole on Reflux Esophagitis

Objective To study the effect of mosapride and omeprazole on treatment of reflux esophagitis(RE).Methods 100 RE patients were randomly divided into two groups,the treatment group(50 cases):5 mg of mosapride tid,20 mg of omeprazole qd were taken orally;the control group(50 cases):20 mg omeprazole qd were taken orally.The symptoms were evaluated from pretreatment to every two weeks after the treatment.Recheck the endoscope findings at the end of 6 weeks.24-hour esophageal pH was performed in two groups.Results The clinical curative rates were 100% in the treatment group and 88% in the control group,the efficient rate evaluation under endoscope were 96%,84% respectively.After 6 weeks,the total number of pH4 and the total percentage of pH4 were decreased in two group(P0.05).There was significant difference between the two groups(P0.05).Conclusion The effect of mosapride combined with omeprazole on treating the reflux esophagitis was obviously superior to the other group.