Comparison of the Effects of Amoxicillin Sodium and Clavulanate Potassium Administered by Two Different Dosage Regimens

OBJECTIVE: To compare the effects of Amoxicillin sodium and clavulanate potassium administered by two different dosage regimens.METHODS: 156 children with lower respiratory tract bacterial infections were randomly divided into two groups(Group A and Group B),and were respectively treated 7～ 14d with amoxicillin sodium and clavulanate potassium by 100mg· kg-1,qd,and 50mg· kg-1,q12h.RESULTS: There were no significant differences(P0.05) between the two groups with mild and moderate lower respiratory tract bacterial infections,but the differences were significant(P0.01) between the two groups with severe lower respiratory tract bacterial infections.CONCLUSION: Amoxicillin sodium and clavulanate potassium given by intravenous drip once daily is efficacious and feasible for patients with mild and moderate lower respiratory tract bacterial infections,while amoxicillin sodium and clavulanate potassium should be given by intravenous drip twice daily for patients with severe lower respiratory tract bacterial infections.