Expressions of Pokemon mRNA and c-myc in breast carcinoma and their correlation

Objective To explore the expressions of Pokemon mRNA and proto-oncogene c-myc in breast cancer and their relation with carcinogenesis and metastasis.Methods From January to October 2008,45 samples of invasive ductal carcinoma,20 samples of pericancer tissue and 20 samples of normal breast tissue were collected for the study. All study subjects were female,aged 23 to 69 years. All samples were confirmed pathologically. The expression of Pokemon mRNA was examined using in situ hybridization and the expression of c-myc was tested using immunohistochemistry. Chi-square test and Spearman's rank correlation coefficient were used for statistical analysis.Results (1)The rate of positive expression of plasma Pokemon mRNA in breast cancer tissue,pericancer tissue and normal breast tissue was 71.11% (32/45),30.00% (6/20) and 20.00% (4/20) respectively,with statistical difference between the three groups (P=0.000). The rate of positive expression of c-myc in breast cancer tissue,pericancer tissue and normal breast tissue was 86.67% (39/45),60. 00% (12/20) and 50.00% (10/20) respectively,with statistical difference between the three groups (P=0.004). (2)The positive expressions of Pokemon mRNA and c-myc in breast cancer were correlated with breast cancer axillary lymph node metastasis (P=0.012,P=0.027). (3)There was a positive correlation between Pokemon mRNA and c-myc (r=0.585,P0.000).Conclusions Pokemon mRNA and c-myc participate in the pathogenesis and metastasis of breast cancer,and there is a correlation between Pokemon mRNA and c-myc.