Relationship between expression of MTA gene1 and clinicopathological features of oral squamous cell carcinoma

Objective:To study the expression of metastasis-associated gene1(MTA1)in tumorigenesis and progression of oral squamous cell carcinoma(OSCC).Methods:MTA1 protein expression and its relation to clinico-pathological features of OSCC were examined in 20 normal oral tissues and 54 OSCC by immunohistochemical SP methods.Results:The overexpression rate of MTA1 in OSCC was 72.2%(39/54),which was significant higher than that of the control group 25%(5/15)(P0.005).The overexpression of MTA1 among the lower differentiated tissues were significant higher than the higher differentiated tissues of OSCC(P0.05),and the findings among the groups of intramuscular infiltration were similar higher than the group of nonintramuscular infiltration,the Ⅲ,Ⅳ clinical stages higher than Ⅰ,Ⅱ clinical stages,and lymph node involvement higher than the non-lymph node involvement of OSCC(P0.05).Conclusions:The overexpression of MTA1 might play an important role in the pathogenesis and development of OSCC,and it might be a target for the therapy and prognostic indicator of OSCC.