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Expression of CXCR7 in oral squamous cell carcinoma

Shan Liu

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Abstract

Objective: To explore the expression of CXCR7 in oral squamous cell carcinoma(OSCC) and to evaluate the expression of CXCR7 and the clinicopathology factors of OSCC.Methods: CXCR7 protein expression and its relation to clinico-pathological features of OSCC were examined in 20 normal oral tissues and 48 OSCC by immunohistochemical SP methods.Results: The overexpression rate of CXCR7 in OSCC was 81.2%(39/48),which was significant higher than that of the control group 25%(5/20)(P0.005);The overexpression of CXCR7 among the lower differentiated tissues were significant higher than the middle/ higher differentiated tissues of OSCC(P0.05),and the findings were similar among the groups of the Ⅲ、Ⅳ clinical stages than Ⅰ、Ⅱ clinical stages,and lymph node involvement than the non-lymph node involvement of OSCC(P0.05).Conclusion: The overexpression of CXCR7 might be play an important role in the pathogenesis and development of OSCC,and it might be a target for the therapy and prognostic indicator of OSCC.

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What this paper is about

Objective: To explore the expression of CXCR7 in oral squamous cell carcinoma(OSCC) and to evaluate the expression of CXCR7 and the clinicopathology factors of OSCC.Methods: CXCR7 protein expression and its relation to clinico-pathological features of OSCC were examined in 20 normal oral tissues and 48 OSCC by immunohistochemical SP methods.Results: The overexpression rate of CXCR7 in OSCC was 81.2%(39/48),which was significant higher than that of the control group 25%(5/20)(P0.005);The overexpression of CXCR7 among the lower differentiated tissues were significant higher than the middle/ higher differentiated tissues of OSCC(P0.05),and the findings were similar among the groups of the Ⅲ、Ⅳ clinical stages than Ⅰ、Ⅱ clinical stages,and lymph node involvement than the non-lymph node involvement of OSCC(P0.05).Conclusion: The overexpression of CXCR7 might be play an important role in the pathogenesis and development of OSCC,and it might be a target for the therapy and prognostic indicator of OSCC.

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Available abstract

Objective: To explore the expression of CXCR7 in oral squamous cell carcinoma(OSCC) and to evaluate the expression of CXCR7 and the clinicopathology factors of OSCC.Methods: CXCR7 protein expression and its relation to clinico-pathological features of OSCC were examined in 20 normal oral tissues and 48 OSCC by immunohistochemical SP methods.Results: The overexpression rate of CXCR7 in OSCC was 81.2%(39/48),which was significant higher than that of the control group 25%(5/20)(P0.005);The overexpression of CXCR7 among the lower differentiated tissues were significant higher than the middle/ higher differentiated tissues of OSCC(P0.05),and the findings were similar among the groups of the Ⅲ、Ⅳ clinical stages than Ⅰ、Ⅱ clinical stages,and lymph node involvement than the non-lymph node involvement of OSCC(P0.05).Conclusion: The overexpression of CXCR7 might be play an important role in the pathogenesis and development of OSCC,and it might be a target for the therapy and prognostic indicator of OSCC.

Key concepts: Medicine, Pathological, Immunohistochemistry, Basal cell, Lymph node, Pathogenesis, Cancer research, Cell

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