The measurement of thrombomodumin,thrombin-antithrombin and D-dimer in plasma from patients with disseminated intravascular coagulation and its diagnostic significance

Objective To analyse the relationship between the diagnosis of disseminated intravascular coagulation(DIC) and the level of Thrombomodumin(TM),thrombin-antithrombin(TAT) and D-dimer in plasma from 67 patients with disseminated intravascular coagulation(DIC).Methods The levels of TM,TAT and D-dimer were measured by a two antibody sandwich enzyme linked immunosorbent assay and a latex aggregation assay.Results The levels of TM,TAT and D-dimer in plasma of patients with DIC were higher than those in control group(P0.01);The level of TM and D-dimer were gradually ascended with DIC developing(P0.01),while the level of TAT did not show the same changes.Conclusion The measurement of different marker of DIC not only helps to diagnose early stage of DIC,but also has the indication to judge the clinical stage of DIC.