Effect of adefovir dipivoxil combined with lamivudine in treantment of chronic hepatits B patients with HBeAg positive after lamivudine resistance

Objective To investigate the value of adefovir dipivoxil combined with lamivudine treatment after lamivudine resistance in chronic hepatitis B patients with HBeAg positive.Methods Patients were divided into two groups.Group A were treated with lamivudine associated with adefovir dipivoxil after lamivudine resistance.Group B were treated with adefovir dipivoxil instead of lamivudine.HBV DNA was detected by real-time PCR,and HBV markers were detected by ELISA.ALT and AST were also detected.Results After 48 weeks treatment,the normalization rate of ALT in group A was 88.6%,the rate of HBV DNA undetectable was 80.5%,the rate of HBeAg undetectable was 35.8%,and anti-HBe serum conversion rate was 16.7%.Meanwhile,the normalization rate of ALT in group B was 77.8%,the rate of HBV DNA undetectable was 63.9%,the rate of HBeAg undetectable was 16.7%,and anti-HBe serum conversion rate was 13.0%.All indexes in group A were obviously higher than those in group B,with statistical difference.Conclusions Effect of lamivudine associated with adefovir dipivoxil in treatment of chronic hepatitis B patients after lamivudine resistance is better than swiching to adefovir dipivoxil.