The Effect of combined Adefovir dipivoxil and Lamivudine therapy on Lamivudine resistant Hepatitis B virus infection

Objective To evaluate the therapeutic efficacy of combined Adefovir dipivoxil and Lamivudine therapy on Lamivudine resistant Hepatitis B virus (HBV) infection.Methods A total of 152 Lamivudine resistant chronic hepatitis B patients were randomly allocated to Adefovir dipivoxil treatment (n=76)and combined Adefovir with Lamivudine treatment group (n=76).Both groups were given the routine dose for 96 weeks.Serum HBV DNA level was measured by quantitative PCR at 12,24,48 and 96 weeks.The levels of ALT and HBeAg were also measured.Results At 12 th week of treatment,HBV DNA and ALT levels were decreased significantly in the combined treatment group than the Adefovir group.At week 24 and 48,there was no difference in HBV DNA negative and normal ALT patients in both groups.At 96 th week of treatment,HBV DNA and ALT were recurrent in Adefovir group.Furthermore,there was no sig41nificant difference in HBeAg negative conversion in both groups.Conclusion Lamivudine combined with Adefovir dipivoxil results in a low resistant rate and is more effective than Adefovir alone.