Effect of adefovir dipivoxil initial treatment and adefovir dipivoxil associated with lamivudine treatment after lamivudine resistance in chronic hepatitis B therapy

Objective To observe the effect of adefovir dipivoxil initial treatment and adefovir dipivoxil associated with lamivudine treantment after lamivudine resistance in chronic hepatitis B therapy.Methods Total of 45 patients were divided into two groups.Group A were treated by lamivudine associated with adefovir dipivoxil after lamivudine resistance.Group B were treated by adefovir dipivoxil as initial treatment.Liver function,kidney function and HBV DNA were detected before treatment and 12,24,36 and 48 weeks after treatment.Results After 12 and 24 weeks treatment,the rate of HBV DNA undetectable in group A was obviously higher than that in group B,with statistical difference.After 48 weeks treatment,the quantitation and undetectable rate of HBV DNA,the normalization rate of ALT were not statistically significant.Normal kidney function and no adverse effect were found during treatment in two groups.Conclusions Effect of chronic hepatitis B therapy by adefovir dipivoxil initial treatment and lamivudine associated with adefovir dipivoxil after lamivudine resistance were equally effective,which deserves continuative exploration.