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2010•Henan Journal of Preventive MedicineRequires access

The Toxicological Assessment on Safety of Compound Capsule of Soy Isoflavone

Yan Zhang

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Abstract

Aim To evaluate the safety on compound capsule of soy isoflavone.Methods The acute toxicity,Ames test,bone marrow cell micronucleus test,mice sperm abnormality test and 30 days feeding test were used in this study according to the procedures for toxicological assessment of food.Results The value of MTD for mice was more than 10.0 g/kgBW,being involved in nontoxic grade;the results of Ames test,bone marrow cell micronucleus test,mice sperm abnormality test were negative;all indexes in 30 days feeding test were not abnormal.Conclusion The compound capsule of soy isoflavone was safe in this study.

About this research paper

What this paper is about

Aim To evaluate the safety on compound capsule of soy isoflavone.Methods The acute toxicity,Ames test,bone marrow cell micronucleus test,mice sperm abnormality test and 30 days feeding test were used in this study according to the procedures for toxicological assessment of food.Results The value of MTD for mice was more than 10.0 g/kgBW,being involved in nontoxic grade;the results of Ames test,bone marrow cell micronucleus test,mice sperm abnormality test were negative;all indexes in 30 days feeding test were not abnormal.Conclusion The compound capsule of soy isoflavone was safe in this study.

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Available abstract

Aim To evaluate the safety on compound capsule of soy isoflavone.Methods The acute toxicity,Ames test,bone marrow cell micronucleus test,mice sperm abnormality test and 30 days feeding test were used in this study according to the procedures for toxicological assessment of food.Results The value of MTD for mice was more than 10.0 g/kgBW,being involved in nontoxic grade;the results of Ames test,bone marrow cell micronucleus test,mice sperm abnormality test were negative;all indexes in 30 days feeding test were not abnormal.Conclusion The compound capsule of soy isoflavone was safe in this study.

Key concepts: Ames test, Micronucleus test, Sperm, SOY ISOFLAVONES, Capsule, Bone marrow, Abnormality, Medicine

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