2012•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access
Effect of bizhongxiao decoction and its decomposed formulas on collagen-induced arthritis in rat synovial effects of IL-1 and TNF
Hao Zhu
Open publisher page 2 citations
Abstract
【Objective】 To study the effect of bizhongxiao decotion and decompositions on study on IL-1 and TNF-1 of rheuma toid,Arthritis rat,and the mechanism of it.【Methods】 90 healthy normal female SD rats randomly divided into groups,model groups,effect of bizhongxiao decoction unit and heat-clearing and toxicity of traditional Chinese medicine intervention,qushi intervention of traditional Chinese medicine group,activating Chinese herbal medicine intervention group.Apart from the normal group groups using subcutaneous injection of bovine type II collagen in rat established with complete Freund adjuvant in rats with collagen-induced arthritis model,observation on the effect of bizhongxiao decoction and its disassemble formulas on experimental rat inhibition of foot swelling,immunohistochemical detection of various points of inflammatory cytokines in synovial IL-1 and TNF levels.【Results】 Modeled after 21 d,model groups,groups and dismantle groups of effect of bizhongxiao decoction in rats significantly higher than normal levels of TNF and IL-1(P 0.05).And the model set of TNF and IL-1 level is significantly higher than group effect of bizhongxiao decoction and separated groups(P 0.01).With the extended time,a model set of TNF and IL-1 level rising,effect of bizhongxiao decoction on the Group and the split groups gradually reduced.Effect of bizhongxiao decoction on IL-1 and TNF levels below the Group separated groups.All-party group,ingredients 1 group,separated 2 groups,recipes 3 Group in turn weakened.【Conclusion】 The effect of bizhongxiao decoction and its disassembled prescriptions in rats with collagen-induced arthritis model,you can cut inflammation factor IL-1 and TNF levels.