Relationship between the classification of cirrhosis and the level of serum CA125

Objective To investigate the relationship between the different Child-Push classification of liver function and the levels of serum tumor antigen CA125 in cirrhosis patients.Methods Sixty-eight patients with chronic type B hepatitis were divided into no-cirrhosis group and cirrhosis group.The former had 17 patients and the latter,according to cirrhosis Child-Push classification,were divided into grade A,B,C groups with 17 cases respective.In addition,34 healthy people were selected as control group.The level of serum CA125 in all subjects were detected by means of immunohistochemical chemiluminescence.And t-test was used to compare the correlation of the levels of serum CA125 between the no-cirrhosis group and control group as well as cirrhosis patients.Results In the levels of serum CA125,there was no significant difference between the no-cirrhosis group [(10.61±5.94)U/ml] and the control group [(9.92±5.43 )U /ml] (P0.05),and significat higher in the cirrhosis group [(86.78±55.43)U/ml] than in the control group [(23.32±4.83)U/ml] (P0.01),and significant higher in the grade A group than in the no-cirrhotic group and the control group,and were significant differences in the grade B[(43.21±10.57)U/ml],grade C[(239.32±90.83)U/ml] groups than in the no-cirrhotic group and the control group(P 0.05,P 0.01),and significant differences in the grade A group than in the grade B and grade C groups(P 0.01).The liver functional classification in cirrhosis group,serum total bilirubin and prothrombin time is correlated positively with the level of serum CA125 (r=0.347,0.318,0.329,all of the value P were0.01) and the level of serum albumin was correlated negative with the level of serum CA125 (r=-0.309,P0.01).Conclusion The level of serum CA125 in patients with cirrhosis is closely correlated with the injury degree of liver function,and the level of serum CA125 in patients with cirrhosis can be regarded as a reference index for the injury degree of liver function and prognosis.The patients with elevated level of serum CA125 should have a positive treatment of liver protection,anti-virus and anti-liver fibrosis.