Relationship between E-selectin gene A561C polymorphism and essential hypertension

Objective To explore the relationship of the polymorphism of E-selectin gene A561C and essential hypertension (EH) among Chinese people. Methods Genotypes of E-selectin were analyzed in 95 EH patients with age ≤70 and 101 normal controls people matched in age and gender by polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP). Serum levels of lipid, glucose, urea and creatinine were measured by biochemical techniques. Plasma soluble E-selectin were measured by enzyme-linked immunosorbent assay(ELISA). Results The frequency of E-selection genotypes AA, AC and CC in EH group were significantly higher than normal group (P0.05). The frequencies of A and C allele in EH group were significantly lower than normal group (P0.05). Relative risk analysis of genotypic frequency indicated that the risk of EH in AC genotype was 2.73 times higher than in AA genotype (OR=2.73,95%CI=1.10-6.91). Conclusion E-selectin gene A561C polymorphism can significantly affect hypertension, C allele may be a risk factor of essential hypertension.