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Correlation between degree of obesity and insulin resistance in patients with nonalcoholic fatty liver disease

Deng Yin-qua

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Abstract

Objective To investigate the correlation between degree of obesity and insulin resistance(IR) in patients with nonalcoholic fatty liver disease(NAFLD).Methods A total of 168 patients with NAFLD were enrolled and 32 healthy subjects were served as controls spontaneously.Body height,weight,fasting blood-glucose(FPG) and fasting insulin(FINS) were recorded and body mass index(BMI) and homeostasis model assessment of insulin resistance index(HOMA-IRI) were calculated.Results Levels of BMI,FPG,FINS,HOMA-IRI in patients with NAFLD were all elevated as compared with the controls(all P 0.05).Meanwhile,with the progressive development of obesity,the IR was gradually enhanced(all P 0.05).Conclusions Hyperinsulinemia and IR may occurred in patients with NAFLD.Moreover,Obesity can aggravate IR and induce secondary glycometabolic disorder.

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Objective To investigate the correlation between degree of obesity and insulin resistance(IR) in patients with nonalcoholic fatty liver disease(NAFLD).Methods A total of 168 patients with NAFLD were enrolled and 32 healthy subjects were served as controls spontaneously.Body height,weight,fasting blood-glucose(FPG) and fasting insulin(FINS) were recorded and body mass index(BMI) and homeostasis model assessment of insulin resistance index(HOMA-IRI) were calculated.Results Levels of BMI,FPG,FINS,HOMA-IRI in patients with NAFLD were all elevated as compared with the controls(all P 0.05).Meanwhile,with the progressive development of obesity,the IR was gradually enhanced(all P 0.05).Conclusions Hyperinsulinemia and IR may occurred in patients with NAFLD.Moreover,Obesity can aggravate IR and induce secondary glycometabolic disorder.

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Available abstract

Objective To investigate the correlation between degree of obesity and insulin resistance(IR) in patients with nonalcoholic fatty liver disease(NAFLD).Methods A total of 168 patients with NAFLD were enrolled and 32 healthy subjects were served as controls spontaneously.Body height,weight,fasting blood-glucose(FPG) and fasting insulin(FINS) were recorded and body mass index(BMI) and homeostasis model assessment of insulin resistance index(HOMA-IRI) were calculated.Results Levels of BMI,FPG,FINS,HOMA-IRI in patients with NAFLD were all elevated as compared with the controls(all P 0.05).Meanwhile,with the progressive development of obesity,the IR was gradually enhanced(all P 0.05).Conclusions Hyperinsulinemia and IR may occurred in patients with NAFLD.Moreover,Obesity can aggravate IR and induce secondary glycometabolic disorder.

Key concepts: Hyperinsulinemia, Nonalcoholic fatty liver disease, Insulin resistance, Internal medicine, Medicine, Body mass index, Obesity, Endocrinology

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