Diabetic nephropathy(DN) Diagnosis Based on Quantitative Measurements of Serum Cys-C and β_2-MG

Objective To evaluate the diagnosis value of serum Cys-C and β2-MG levels in diabetic nephropathy(DN).Methods The turbidimetric immunoassay method was adopted to detect the serum Cys-C and β2-MG levels in 162 type 2 diabetic patients,which contain 61 cases without urinary albumin excretion(group Ⅰ),48 cases with low urinary albumin concentration(group Ⅱ),and 53 DN patients(group Ⅲ).Results There were no significant differences for the serum Cys-C and β2-MG levels between health control group and group I;however,they were significantly lower than that in both group Ⅱ and group Ⅲ(P0.05).The highest serum Cys-C and β2-MG levels were observed in group Ⅲ,which significantly differed with other groups(P0.05).When the two serum biomarkers were used for DN diagnosis,the area under ROC curve were 0.978(0.956-1.000) for Cys-C and 0.871(0.942-1.000) for β2-MG,which combined with the Youden index of 1.952 and 1.867,respectively.Conclusion The serum levels of Cys-C and β2-MG could be employed as biomarkers in the diagnosis of DN.However,the diagnosis power was relatively higher for Cys-C than β2-MG.