Investigation of lipid profile and significance evaluation of ApoB/ApoAI ratio on coronary heart disease patients in central plains region of China

Objective:Through analyses of lipid profile on coronary heart disease patients in central plains region of china,we investigated whether the necessity and advantage of ApoB/ApoAI ratio could be a risk factor in coronary heart disease(CHD).Method:Serum lipid and apolipoprotein of control and CHD patients confirmed by coronary angiography were chemical analyzed.The percentage of different lipid levels divided by Chinese lipid guideline was investigated and compared by t test in two groups.Correlations of different lipid profile were analyzed statistically;and significant difference of correlation coefficient was compared through fisher z transformation.Result:①the value of Total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),non-high density liprotein cholesterol(non-HDL-C),apolipoprotein B(ApoB),TC/HDL-C ratio and ApoB/ApoAI ratio in coronary heart disease group were significant higher than those in control group(P0.05),while the concentration of triglyceride(TG) had no significant difference in two groups.The concentration of high density lipoprotein cholesterol(HDL-C) and apolipoprotein AI(ApoAI) were lower significantly than those in control group(P=0.003 and P=0.002,respectively).②the percentage of HDL-C in different levels in CHD groups had significant difference than those in control groups(P=0.002),while the percentage of TC and LDL-C in two groups were no significant difference(P0.05).③LDL-C and non-HDL-C had closest correlation(r=0.959),and two correlation coefficients of LDL-C with ApoB/ApoAI and non-HDL-C with ApoB/ApoAI were not significant different(P0.05).But these two indexes had significant difference,respectively,compared with the correlation coefficients of ApoB/ApoAI with ApoB and ApoB/ApoAI with TC/HDL-C(P0.05).Conclusion:The CHD patients in central plains region of China were characteristic of low HDL-C concentration.For the statistical difference among lipid profile,ApoB/ApoAI ratio would be ideal marker and therapy target in these patients.