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[Chorionic villus cell culture and karyotype analysis in 110 cases of early spontaneous abortion].

Li Xiong, Jie Liu, Kang Deng, Siping Liu, Bei Jia, Ruifeng Wu, Mei Zhong, Rong Zeng

Abstract

OBJECTIVE: To investigate the value of fetal chromosomal karyotype analysis in cases of early spontaneous abortion. METHODS: Chorionic villus specimens obtained from 110 cases of early spontaneous abortion were cultured for karyotype analysis. RESULTS: Of the 110 cases, chorionic villus was successfully cultured in 103 cases (93.7%), and abnormal embryo karyotypes were identified in 52 cases (50.5%). Trisomy was the most frequent embryo karyotype abnormalities in these cases, and chromosomal aberration occurred in 29 cases (52.9%) of the first spontaneous abortion and in 23 cases (42.6%) of repeated abortions. Female fetuses accounted for 75.5% (78 cases) in the spontaneously aborted fetuses and for 67.3% (35 cases) in fetuses with chromosomal abnormalities. CONCLUSION: Embryo chromosomal abnormality is the most important reason of early spontaneous abortion, and karyotype analysis of the villus helps identify the causes of abortion and ensure the success of the next pregnancy.

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Available abstract

Key concepts: Karyotype, Abortion, Chorionic villi, Chromosomal Abnormality, Trisomy, Chorionic villus sampling, Products of conception, Gynecology