Chromosomal karyotype in chorionic villi in patients with first spontaneous abortion or recurrent spontaneous abortion

Objective:To investigate the correlation between abnormal karyotypes of fetal chorionic villus cells and first spontaneous abortion,recurrent spontaneous abortion.Methods:The subjects were divided into two groups:early recurrent abortion group(n=57) and first early spontaneous abortion group(n=47).Fetal villus tissues were collected in uterine curettage for karyotyping by the conventional G-banding chromosome analysis.Results:Chromosome number abnormality was found in 22 cases(39.3%) and 30 cases(66.7%) in recurrent abortion group and first early spontaneous abortion group,respectively.Significant lower abnormal karyotype rate or triploid was observed in recurrent abortion group than that in first early spontaneous abortion group(42.9% vs 66.7% and 21.4% vs 57.8%,P0.05).However,no significant difference was found in sexual chromosome abnormalities between the two groups(12.5% vs 8.9%,P=0.565).Conclusion:The chromosome abnormality contributs significantly to early spontaneous abortion.However,other predisposing factors should be taken into account in early recurrent abortion.