Pathological observation of adriamycin nephropathy in rats

Aim To establish the model of adriamycin_ induced nephritic syndrome in rats and its pathological change was observed.Methods The model of nephritic syndrome in rats was established by intravenous injection of adriamycin in the dose of 5 mg ·kg-1 and 3 mg ·kg-1 respectively at the first day and 15 th day.The amount of urine protein was measured at the 1?2?3?4?6?8 and 12 th week and the serum biochemical parameters of TG,TCH,BUN,Cr,TP and ALB were detected at the 6 th and 12 th week.Results The urine protein and the serum biochemic parameters were increased significantly,except the TP and ALB, which were decreased.Pathological changes at the sixth week was similar to minimal changes in glomerulonephritis, and at the 12 th week, sclerosis of glomeruli of kidney could be found.Conclusion After first injection, the changes of kidney were like those in minimal change glomerulonephritis of human being. But after the second injection.The kidney had the changes of focal segmental glomeralosclerosis.